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Sheyn Dmitriy

Sheyn Dmitriy

Cedars-Sinai Medical Center
Orthopedics
Los Angeles, United States of America

This field of gene-and-stem cell therapy holds a great therapeutic potential. During my PhD at Hebrew University of Jerusalem, I have developed an efficient and easily reproducible method to modify stem cells and to regenerate bone defects and generate new bone tissue for spinal fusion. The cell therapy approach was tested and found biomechanically comparable to the native bone. This is of enormous importance since the current clinical practice mostly involves artificial materials that are extremely far from the native tissues by their biomechanical properties, which often causes rejection and failure. During my postdoc at Cedars-Sinai Medical Center in Los Angeles, I studied the effect of PTH on bone repair and stem cell recruitment to the injury site in osteoporotic and healthy animal models. I have developed a protocol to differentiate induced pluripotent stem cells (iPSCs) into a new stem cell entity, characterized it and used for segmental bone defects repair. Currently I’m developing new applications for adult and pluripotent stem cells in the field of skeletal tissue regeneration, particularly focusing on the soft tissues of knee and intervertebral disc. Sports medicine is of particular interest of mine, since the soft tissue injuries have very limited solutions these days. I’m applying the knowledge and expertise I gained during the years in the genetically modified stem cell research, translational large animal models and imaging to bring new remedies to the soft tissue injuries.

5 February (Wednesday)

  • 14:30 - 16:00
    Session 2
    • 15:00 - 15:30
      Orthopedic Stem Cell Research Lab, Regenerative Medicine Institute, Cedars-Sinai: Identification of Cell and Protein Biomarkers in PRP to Improve Individual Pain Outcomes in Knee OA
      We aim to identify cell and protein biomarkers in platelet-rich plasma (PRP) that correlate with reduced knee osteoarthritis (OA)-associated pain levels post-PRP treatment to allow for prediction of PRP therapy efficacy. This study will provide a thorough analysis of PRP cell and protein biomarker composition and its effect on clinical outcomes and thus will allow to identify the main contributors to PRP’s efficacy. These findings will allow to define new standards of PRP composition, leading to higher success rates in PRP therapy for knee OA.