This field of gene-and-stem cell therapy holds a great therapeutic potential. During my PhD at Hebrew University of Jerusalem, I have developed an efficient and easily reproducible method to modify stem cells and to regenerate bone defects and generate new bone tissue for spinal fusion. The cell therapy approach was tested and found biomechanically comparable to the native bone. This is of enormous importance since the current clinical practice mostly involves artificial materials that are extremely far from the native tissues by their biomechanical properties, which often causes rejection and failure. During my postdoc at Cedars-Sinai Medical Center in Los Angeles, I studied the effect of PTH on bone repair and stem cell recruitment to the injury site in osteoporotic and healthy animal models. I have developed a protocol to differentiate induced pluripotent stem cells (iPSCs) into a new stem cell entity, characterized it and used for segmental bone defects repair. Currently I’m developing new applications for adult and pluripotent stem cells in the field of skeletal tissue regeneration, particularly focusing on the soft tissues of knee and intervertebral disc. Sports medicine is of particular interest of mine, since the soft tissue injuries have very limited solutions these days. I’m applying the knowledge and expertise I gained during the years in the genetically modified stem cell research, translational large animal models and imaging to bring new remedies to the soft tissue injuries.