My clinical education is in orthopedics surgery, but my early background started in a laboratory where I was involved in the early steps of oncogene mediated sarcoma cancerogenesis, which is the subject of my PhD thesis. Due to this biological background my interest deeply evolved in orthopedics where the biological aspects are relevant and improvements for treatments could take advantage of biological studies.
My research group is focused on two main research areas: osteoncology, i.e. the study of bone alterations in cancer patients, and regenerative medicine applied to bone and cartilagine reconstruction, i.e. the process of replacement and regeneration of bone tissue for the treatment of fractures and / or musculoskeletal disorders. In the osteocological field, our interest is focused on understanding the molecular mechanisms that regulate the development of bone metastases in frequent and aggressive solid tumors, such as non-small cell lung cancer, breast cancer, adenocarcinoma of the kidney. Specifically, the research is aimed at defining the role of cancer stem cells in the formation of metastases and their interaction between bone and the immune system. In the field of regenerative medicine, studies are aimed at the use of mesenchymal stem cells derived from adipose tissue for the treatment of knee and hip arthritis, thanks to their ability to differentiate into osteoblasts, chondrocytes, myoblasts, stromal cells and therefore potentially repairing damaged tissues, generating bone and cartilage.
My publications fully addressed all these topics.