Macau – sometimes spelled Macao – is one of the most intriguing destinations in Asia. It was one of the first ports of call for Portuguese merchants and missionaries in the 16th century, and later became a fully fledged, if somewhat lackadaisical, colony. Handed back to China in 1999, it has since reinvented itself. Situated on the western bank of the Pearl River Delta, just an hour’s ferry or a 15-minute helicopter ride from Hong Kong, this unique region combines a vibrant Portuguese heritage with colourful Chinese roots. Designated as a Special Administrative Region (SAR) of China, Macao is known for its premier shopping, dining and entertainment. Discover famed sites in the city’s historic center near Senado Square, part of the city’s UNESCO World Heritage site. Stroll along the paved streets, stopping at diverse boutiques offering regional handicrafts and Chinese restaurants housed in historic Cino-Portuguese buildings. Marvel at the historic ruins, mystical temples and impressive fortresses, which illustrate the evolution of dual Western and Chinese civilizations spanning over four and a half centuries. Building on the success of previous ICRS meetings this meeting promises a state of the art summary of current and future techniques in cartilage repair and will also emphasize and further develop similarities and differences between cartilage injury and early Osteoarthritis. These topics will be elucidated through sessions covering the latest approaches towards cartilage injury and early Osteoarthritis from the view point of basic science, clinical science and clinical techniques to address the problems and issues that we encounter on a daily basis.