Mei Wan, Ph.D. is Frank J. Frassica Professor at the Department of Orthopaedic Surgery, Johns
Hopkins University. She studies the contribution of fundamental aging processes, particularly
cellular senescence, to the development of skeletal disorders. Her team was the first to identify
that senescent preosteoclast secretome promotes metabolic syndrome associated osteoarthritis
(OA) through COX2. Recently, her team uncovered that glucocorticoid treatment induces a lipid
metabolic circuit that robustly triggers the senescence of bone marrow adipocytes that, in turn,
mediates glucocorticoid-induced bone deterioration. This work was just accepted in Cell
Metabolism. The impact of Dr. Wan’s research extends across different disciplines as testified by
her publication record, which includes papers in Cell Metabolism, Nature Communications,
Journal Clinical Investigation, eLife, Gene & Development, PNAS, Stem Cells, Bone Research,
etc. Her research program has been continuously funded by NIH. Dr. Wan has chaired multiple
sessions at annual meetings of ASBMR and the International Conference on Tissue Science and
Regenerative Medicine. Dr. Wan has served on the editorial boards of two leading skeletal-related
journals, the Journal of Bone and Mineral Research and Bone Research. Since 2021, she serves
on the Reviewing Editor Board of eLife.